The following are relevant articles that provide more in-depth information on mTOR. Last updated August 2008.
Dancey JE. Therapeutic Targets: mTOR and Related Pathways. Cancer Biol Ther. 2006. 5:1065-1073.
A preclinical and clinical overview of mTOR in human cancer.
Abraham RT, Gibbons JJ. The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res. 2007 13:3109-31140.
Highlights recent advances in our understanding of mTOR and the implications of these findings for the clinical application of mTOR inhibitors in cancer patients.
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441:424-430.
Reviews recent findings which highlight how RAS and mTOR pathways contribute to tumorigenesis and discusses addressing issues faced in designing rational therapies for cancer patients.
Wullschleger S, Loewith R, Hall, MN. TOR Signaling in Growth and Metabolism. Cell. 2006 124:471-476.
Article reviews the mammalian TOR complexes and the signaling branches they mediate suggesting that inhibitors of mammalian TOR may be useful in the treatment of cancer.
